Andrographolide : Potency as Antiatherosclerosis in Il-1β Cytokine

The focus is how the role of cytokines in atherosclerosis as a chronic inflammatory disease, it known that regulate complex responses atherosclerotic plaques, especially IL-1β. Sambiloto (Andrographis paniculata) plant with various pharmacological activities. Andrographolide (AND) main bioactive compound diterpene lactone group. This literature study aims to assess potential AND on proinflammatory cytokine IL-1 β an antiatherosclerosis. type research qualitative review studies using sambiloto plants or andrographolide compounds (AND). Search Google Scholar database. Keywords used "Andrographis paniculata, andrographolide, IL-1β, Atherosclerosis. results showed has effects anti-inflammatory, antiatherosclerosis well cardiovascular-related diseases. There are not many articles activity IL-1β against atherosclerosis, but can provide inhibitory inflammation. Not researchers have discussed antiatherosclerotic therapeutic targets, from strong inhibiting secretion β.